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Sales of veterinary antimicrobial agents in 31 European countries in 2019 and 2020
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Sales of veterinary antimicrobial agents in 31 European countries in 2019 and 2020

Trends from 2010 to 2020 : eleventh ESVAC report

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A total of 31 European countries — 30 EU/EEA countries (at the time of calendar years covered in this report) and Switzerland — submitted antimicrobial veterinary medicinal products (VMPs) sales or prescription (two countries) data to the European Medicines Agency for 2019 and 2020. A population correction unit (PCU) is applied as a proxy for the size of the food-producing animal population (including all horses). The main indicator used in the current report to express the sales of antimicrobial VMPs is milligrams of active substance sold per population correction unit — mg/PCU. Following the update to the ESVAC protocol in March 2021 and the subsequent update of conversion factors, historical updates of conversion factors were made to all previously reported data. Countries submitted 2020 data in compliance with the updated ESVAC protocol, including the rules for reporting the qualitative and quantitative composition of antimicrobial VMPs (variable strength). The vast majority of the countries also aligned their 2019 data to the requirements in the new protocol. The report presents data for the years 2019 and 2020, with a focus on the most recent data (2020). Sales data for 2019 are displayed in the changes over time section (Section 2.8) and changes in the overall sales between 2019 and 2020 are addressed in the discussion (Section 3). Data for 2019 are available in the ESVAC interactive database. Those figures and tables that cannot be directly extracted from the online application can be found in Annex 2 of this report. Focusing on the most recent data, in the sales for 2020, expressed as mg/PCU, a large difference was observed between the countries with the highest and lowest sales (range from 2.3 mg/PCU to 393.9 mg/PCU and median value of 51.9 mg/PCU). The aggregated value for all 31 countries which reported data in 2020 was 89.0 mg/PCU. Of the overall sales of antimicrobials in the 31 countries in 2020, the largest amounts, as a proportion of total mg/PCU, were accounted for by penicillins (31.1%), tetracyclines (26.7%) and sulfonamides (9.9%); 2019 and 2020 are the first years in which the proportion of sales accounted for by penicillins is higher than that for tetracyclines. Overall, in 2020 these three classes accounted for 67.7% of total sales in the 31 countries. The sales patterns of the various antimicrobial classes, expressed as mg/PCU, varied substantially between the 31 countries. In 2020, notable variations between countries were observed with regard to the quantities sold for antimicrobial classes included in the EMA AMEG Category B, i.e. 3rdand 4th-generation cephalosporins, fluoroquinolones, other quinolones and polymyxins, with sales for each class ranging from <0.01 to 0.7 mg/PCU, <0.01 to 12.9 mg/PCU, 0 to 1.1 mg/PCU and 0 to 15.9 mg/PCU, respectively (Table 5). For these classes, the proportion of aggregated sales (mg/PCU) for food-producing animals in the 31 countries accounted for 0.2%, 2.6%, 0.2% and 2.8% of total sales, respectively (Figure 4). These classes are also considered as critically important antimicrobials (CIAs) with highest priority for human medicine by WHO, which also includes macrolides (and ketolides) in this priority grouping. Macrolides accounted for 8.8% of the total sales of antimicrobials for food-producing animals in the 31 countries in 2020.
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ISSN 2315-1455
ISBN 978-92-9155-067-8
DOI 10.2809/636389
Kataloška številka TC-AE-21-001-EN-N
ISSN 2315-1447
ISBN 978-92-9155-068-5
DOI 10.2809/167341
Kataloška številka TC-AE-21-001-EN-C
PDF
ISSN 2315-1455 ISBN 978-92-9155-067-8 DOI 10.2809/636389 Kataloška številka TC-AE-21-001-EN-N
Tiskana razliičica
ISSN 2315-1447 ISBN 978-92-9155-068-5 DOI 10.2809/167341 Kataloška številka TC-AE-21-001-EN-C
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