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HomeA critical review of studies on the reproductive and developmental toxicity of nanomaterials
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The scope of this project was to perform a critical review of the current knowledge from studies with testing of manufactured nanomaterials for reproductive and developmental toxicity. Relevant literature databases and relevant search terms were identified, and a literature search was conducted in order to identify publications with in vivo data where manufactured nanomaterials have been tested for reproductive and developmental toxicity using an exposure route relevant for human exposure. As a result, 111 publications covering 19 nanomaterials were identified. The publications were further assessed in full text and key information was extracted and transferred into tables for the specific nanomaterial. In order to identify the most relevant studies, each publication was scored for nano-characterisation, reliability/quality of the study, and the relevance in the context of the project. A common overview of the data is given with respect to type of data (kinetic/ distribution data, fertility data, developmental data) and with respect to test species and exposure route used for the testing of each nanomaterial. Based on the data a series of key questions regarding the reproductive and developmental toxicity is -as far as possible- answered and some recommendations for future work are given
- Publicado em:
- Temas: Investigação científica e técnica
- Tema: base de dados , bibliografia , ensaio , nanotecnologia , pesquisa documental , produto manufaturado , projeto de investigação , substância tóxica
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| ISSN | ISBN 978-92-9481-423-4 | DOI 10.2823/421061 | Número de catálogo ED-04-20-176-EN-N |
- Released on EU publications website:
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