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Non-animal methods in science and regulation
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Non-animal methods in science and regulation

EURL ECVAM status report 2024

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The 2024 EURL ECVAM Status Report highlights progress in advancing non-animal methods for science and regulation. Driven by EU-funded collaborations, research focuses on chemical safety assessment, endocrine disruptor identification, and risk assessment, using genomics, in vitro and in silico tools, and AI. EURL ECVAM supports new approach methodologies (NAMs) validation through initiatives such as revising OECD Guidance Document 34, standardising emerging technologies like organ-on-chip, and engaging the EU-NETVAL network. Peer reviews by EURL ECVAM's Scientific Advisory Committee (ESAC) assess the scientific validity of submitted test methods. EURL ECVAM collaborates with international organisations and EU agencies to advance emerging non-animal sciences and technologies, with the goal of integrating them into regulatory practices for chemical hazard and risk assessment. The European Commission's roadmap towards phasing out animal testing is supported, as is the 3Rs (Replacement, Reduction, Refinement) approach in the pharmaceutical sector through the EMA 3Rs Working Party and the EMA Innovation Task Force. Education and training are key to expanded NAMs use. Ultimately, this report provides evidence-based scientific information, aiming to increase NAMs acceptance and implementation globally.
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ISSN 1831-9424
ISBN 978-92-68-25298-7
DOI 10.2760/9648771
Numero di catalogo KJ-01-25-159-EN-N
ISSN 1018-5593
ISBN 978-92-68-25299-4
DOI 10.2760/6735899
Numero di catalogo KJ-01-25-159-EN-C
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ISSN 1831-9424 ISBN 978-92-68-25298-7 DOI 10.2760/9648771 Numero di catalogo KJ-01-25-159-EN-N
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ISSN 1018-5593 ISBN 978-92-68-25299-4 DOI 10.2760/6735899 Numero di catalogo KJ-01-25-159-EN-C
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