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Opinion on use of the threshold of toxicological concern (TTC) approach for human safety assessment of chemical substances with focus on cosmetics and consumer products
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Opinion on use of the threshold of toxicological concern (TTC) approach for human safety assessment of chemical substances with focus on cosmetics and consumer products

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The SCCP (now SCCS)/SCHER/SCHENIHR (SCs) were asked to evaluate potential applications of the Threshold of Toxicological Concern (TTC) approach for human health risk assessment of chemical substances. This opinion focuses on the potential applications of the TTC concept for cosmetics and other consumer products in relation to the mandates of the three SCs. It does not assess application of TTC in other areas, such as food, pharmaceuticals or EU chemical legislation (REACH), although such applications are described for completeness. The SCs addressed the various product categories where the TTC approach was proposed and discussed a possible distinction between intentionally added ingredients and substances present as contaminants or impurities. Classes of chemicals, exposure situations, and toxicity endpoints which may be addressed by using the TTC concept were identified. The quantity and type of information (exposure, toxicity, QSAR, statistics, etc.) required for a particular class of chemicals and/or exposure situation before the TTC concept can be applied in the risk assessment were also discussed. Finally, additional research needed to strengthen the TTC approach and its usefulness was considered.
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ISBN 978-92-79-30699-0
DOI 10.2772/2058
Katalognummer ND-79-13-000-EN-N
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ISSN ISBN 978-92-79-30699-0 DOI 10.2772/2058 Katalognummer ND-79-13-000-EN-N
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