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HomeOpinion on fragrance ingredient Acetylated Vetiver Oil - AVO (Vetiveria zizanioides root extract acetylated)
Submission III : corrigendum of 20-21 June 2019
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1. On the basis of currently available information, does the SCCS consider Acetylated Vetiver Oil (AVO) safe for use as fragrance ingredient in cosmetic leave-on and rinse-off type products in a concentration limit(s) according to the once set up by IFRA as reported above? On the basis of the safety assessment carried out using a conservative approach, the SCCS considers the use of Acetylated Vetiver Oil (AVO) with 1% alpha-tocopherol as a fragrance ingredient in cosmetic leave-on and rinse-off type products safe at the concentrations proposed by IFRA. 2. Does the SCCS have any further scientific concerns with regard to the use of Acetylated Vetiver Oil (AVO) as fragrance ingredient in cosmetic leave-on and rinse-off type products? Acetylated Vetiver Oil (AVO) contains some constituents that belong to the chemical group of aldehydes and ketones that are known to be reactive towards biological entities, such as DNA and proteins. However, the overall health risk of such components is likely to be negligible at the concentrations intended to be used in cosmetics products. The SCCS has noted that Acetylated Vetiver Oil (AVO) is a moderate skin sensitiser in test animals. Considering the results of the HRIPT study and the fact that AVO has been used for years in cosmetics without evidence of sensitising potential, it is unlikely that AVO would be causing contact allergy in humans. Inhalation toxicity of Acetylated Vetiver Oil (AVO) was not assessed in this Opinion because no data were provided. Assessment of the inhalation risk would be needed if AVO was intended to be used in sprayable products.
- Offentliggjort:
- Forfatter(e): Directorate-General for Health and Food Safety (Europa-Kommissionen)
- Emner: Farmaceutisk og kosmetisk industri , Videnskabelig og teknisk forskning
- Emne: allergi , analytisk kemi , EU-forordning , forbrugerbeskyttelse , giftigt stof , kosmetisk produkt , sundhedspolitik , videnskabelig forskning
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| ISSN 1831-4767 | ISBN 978-92-76-15247-7 | DOI 10.2875/96061 | Katalognummer EW-AQ-20-002-EN-N |
- Released on EU publications website:
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