Publications Office of the EU
Establishing the scientific validity of complex in vitro models
DisplayCustomHeader
MyPortal
čeština
BasketSummary
Webový obsah - zobrazení
Publication Detail Actions Portlet

Nástroje

Publication Detail Actions Portlet
 Uživatelské hodnocení
custom-survey-notification
Publication Detail Portlet

Publication detail

Home

Establishing the scientific validity of complex in vitro models

Results of a EURL ECVAM survey

Metadata o publikaci

Complex in vitro models (CIVMs) - such as 3D cell cultures and spheroids, microphysiological systems including organ-on-chip devices, bioreactor cultures or bioprinted tissues – aim to represent higher-level anatomical and physiological aspects of human biology in experimental studies. The underpinning technologies are developing fast and the models and methods being created constitute promising approaches in several different scientific areas with many applications in research and regulatory testing. However, the successful implementation and acceptance of CIVMs is likely to require their proper characterisation, validation or qualification to demonstrate to end-users that they are fit for a particular purpose or context of use. To explore this, the EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) of the European Commission's Joint Research Centre (JRC) conducted a survey to investigate stakeholder opinions and perceived needs. The outcome of the survey showed that i) there is high interest in establishing some kind of assessment approaches for CIVMs; ii) assessment approaches (even if conducted differently) should be adequate not only for regulatory use-contexts, but also address applications in research; and iii) CIVMs are still under (technological and biological) development and are thus not yet mature or standardised enough to enable a consensus on how their assessment should be conducted.
Zobrazit více
Zobrazit méně
ISSN 1831-9424
ISBN 978-92-76-28410-9
DOI 10.2760/376171
Katalogové číslo KJ-NA-30556-EN-N
ISSN 1018-5593
ISBN 978-92-76-28409-3
DOI 10.2760/399535
Katalogové číslo KJ-NA-30556-EN-C
PDF
ISSN 1831-9424 ISBN 978-92-76-28410-9 DOI 10.2760/376171 Katalogové číslo KJ-NA-30556-EN-N
Tištěná podoba
ISSN 1018-5593 ISBN 978-92-76-28409-3 DOI 10.2760/399535 Katalogové číslo KJ-NA-30556-EN-C
  • Released on EU publications website:
Tato publikace je k dispozici ke stažení v online formátu (PDF) a ve formátu vhodném pro tisk (PDF/X). Více informací o tom, jak si vytisknout vlastní kopii publikací EU, naleznete v Často kladené otázky.
Publication Viewer

Prohlížeč dokumentů

Pop up window annotations