Massachusetts Institute of Technology TITJUR Opinion of Mr Advocate General Léger delivered on 24 November 2005. # Massachusetts Institute of Technology. # Reference for a preliminary ruling: Bundesgerichtshof - Germany. # Patent law - Medicinal products - Regulation (EEC) No 1768/92 - Supplementary protection certificate for medicinal products - Concept of 'combination of active ingredients'. # Case C-431/04.