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HomeOpinion on hair dye 1,2,4-trihydroxybenzene (1,2,4-THB)
COLIPA n° A33 (CAS 533-73-3) : submission VI
Opinion on hair dye 1,2,4-trihydroxybenzene (1,2,4-THB)
COLIPA n° A33 (CAS 533-73-3) : submission VI
Publication metadata
1. In light of the data provided, does the SCCS consider 1,2,4-trihydroxybenzene (1,2,4-THB) (A33) safe for use as an auto-oxidative hair dye in permanent hair dye formulations, not requiring the action of peroxide, with a maximum on-head concentration of 2.5%? On the basis of all the data submitted by the Applicant, and the data available in open literature, the SCCS does not consider 1,2,4-trihydroxybenzene safe due to potential genotoxicity when used as an auto-oxidative hair dye component in permanent hair dye formulations. The data provided by the Applicant indicate that consumers would be exposed to unreacted 1,2,4-THB and (semi)quinones during the use of a 1,2,4-THB containing hair dye formulation. The systemic availability of 1,2,4-THB raises the risk of intracellular generation of hydrogen peroxide, as well as potential genotoxicity via DNA adduct formation by 1,2,4-THB and/or (semi)quinones. These aspects have not been addressed in the studies provided in the submission. 2. In light of the data provided, does the SCCS consider 1,2,4-trihydroxybenzene (1,2,4-THB) (A33) safe for use as an auto-oxidative hair dye in hair colour shampoo formulations, not requiring the action of peroxide, with a maximum on-head concentration of 0.7%? See above. 3. Does the SCCS have any further scientific concerns with regard to the use of 1,2,4-trihydroxybenzene (1,2,4-THB) (A33) in cosmetic products?
- Published:
- Corporate author(s): Directorate-General for Health and Food Safety (European Commission)
- Themes: Pharmaceutical and cosmetics industry , Scientific and technical research
- Subject: analytical chemistry , consumer protection , cosmetic product , health policy , toxic substance
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| ISSN 1831-4767 | ISBN 978-92-76-15249-1 | DOI 10.2875/01768 | Catalogue number EW-AQ-20-003-EN-N |
- Released on EU Publications:
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