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HomeSetting priorities for further development and validation of test methods and testing approaches for evaluating endocrine disruptors
Final report
Setting priorities for further development and validation of test methods and testing approaches for evaluating endocrine disruptors
Final report
Publication metadata
Endocrine disruptors (EDs) are substances that can cause harmful effects to the endocrine (hormone) system of both humans and animals. Within human and animal bodies, hormones will act at very small levels and at critical times to regulate e.g. development, growth, metabolism, immunity, behaviour and reproduction. Exposure to endocrine disrupting substances can have life-long effects and the consequences may be passed onto the next generation. The EU has therefore introduced specific legislative obligations aimed at phasing out endocrine disrupting substances. An important factor in the legislative framework and the regulation of chemicals is the availability of methods to identify and assess the hazardous properties of substances. The OECD helps to ensure that test methods (TMs) are internationally and mutually accepted as part of a test guideline (TG) programme. The OECD's Endocrine Disruptor Testing and Assessment Advisory Group coordinates development of testing and assessment approaches for endocrine disruptors. Despite the progress achieved on the development and validation of TGs for evaluation of EDs and associated guidance documents under the OECD auspices over the last 20 years, there are still some gaps and weaknesses in the current test methods for evaluation of EDs. To address these gaps and weaknesses, the European Commission Services organised a European expert workshop in Brussels 30 May – 1 June 2017 with the objectives of: Identifying gaps in test methods; Identifying ways to address those gaps; and prioritising further development and validation of TMs and testing approaches in this area. The workshop followed an earlier JRC expert survey on identification of gaps in available test methods for the evaluation of endocrine disruptors, the results of which were published in a 2017 report.
- Published:
- Corporate author(s): Directorate-General for Environment (European Commission) , Risk & Policy Analysts Limited (RPA) , wca Environment
- Themes: Medical and biological research
- Subject: endocrine disease , endocrine disruptor , health risk , research method , testing , toxic substance
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| ISSN | ISBN 978-92-79-83076-1 | DOI 10.2779/21828 | Catalogue number KH-01-18-423-EN-N |
- Released on EU Publications:
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